Suppression of HIV-1 replication by propolis and its immunoregulatory effect.
Source: Albert Einstein College of Medicine, Department of Pediatrics, Microbiology and Immunology, Bronx, New York 10461, USA.
In the current study we show that PROPOLIS, a non-toxic natural bee-hive product, suppresses HIV-1 replication and modulates in vitro immune responses.
CEM cells were treated with propolis at non-toxic concentrations prior to or following infection with HIV-1. Propolis abolished syncytium formation at 4.5 micrograms/ml and inhibited it at lower doses in a concentration-dependent manner. Propolis decreased p24 antigen production by as much as 90-100% in a concentration-dependent manner. Furthermore, modulation of peripheral blood mononuclear cells (PBMCs) mitogenic responses upon the addition of propolis was noted, reducing the elevated responses to Concanavalin A (Con A) and enhancing suppressed mitogenic responses to pokeweed mitogen (PWM). In summary, propolis may constitute a non-toxic natural product with both anti HIV-1 and immunoregulatory effects.
PMID: 9309384 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances, Grant Support
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Source: Albert Einstein College of Medicine, Department of Pediatrics, Microbiology and Immunology, Bronx, New York 10461, USA.
In the current study we show that PROPOLIS, a non-toxic natural bee-hive product, suppresses HIV-1 replication and modulates in vitro immune responses.
CEM cells were treated with propolis at non-toxic concentrations prior to or following infection with HIV-1. Propolis abolished syncytium formation at 4.5 micrograms/ml and inhibited it at lower doses in a concentration-dependent manner. Propolis decreased p24 antigen production by as much as 90-100% in a concentration-dependent manner. Furthermore, modulation of peripheral blood mononuclear cells (PBMCs) mitogenic responses upon the addition of propolis was noted, reducing the elevated responses to Concanavalin A (Con A) and enhancing suppressed mitogenic responses to pokeweed mitogen (PWM). In summary, propolis may constitute a non-toxic natural product with both anti HIV-1 and immunoregulatory effects.
PMID: 9309384 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances, Grant Support
LinkOut - more resources
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